Tapering off opioids: When and how

If you've taken opioid medications for more than a couple of weeks, it's likely you need to stop soon — and stop slowly, to avoid severe symptoms of withdrawal.

By Mayo Clinic Staff

When it's time to stop using the opioid medication

Opioids are powerful painkillers. Despite the risks associated with opioid use — including high rates of abuse, addiction and accidental overdose — they are still the most effective option for acute, short-term pain. Your doctor may prescribe opioids to help you get through a few days of severe pain after surgery or a traumatic injury. Opioid medications also play an important role in treating cancer-related pain and, rarely, chronic, noncancer pain when other treatments haven't worked.

If you've taken opioids for less than two weeks, you should be able to simply stop these medications as soon as your prescribed course of pills runs out, if not before. Ask your doctor if you're not sure when you can stop your medications.

If you've taken opioid medications for more than two weeks, you may also need to stop using these medications as soon as possible to prevent serious consequences. Common signs that it's time to get off opioids include serious side effects, reduced pain relief from the same dose of medications over time (tolerance), or behaviors that raise concerns about misuse, abuse or addiction.

Don't try to go cold turkey on your own. When it's time for you to stop taking opioids, ask for your doctor's help to develop a medication withdrawal plan (called a taper) that gradually reduces the amount of medication you take. Opioid withdrawal can be dangerous, and symptoms can be severe. Depending on the type and dose of drug you've been taking, it may take weeks or even months to gradually and safely reduce your dose and get off your opioid medication.

Stopping opioids can be difficult, but you can do it. You're much more likely to succeed if you partner with your doctor, plan your taper schedule, manage your symptoms and learn alternative ways to cope with pain.

Not sure if your medication is considered an opioid?

Opioid medications on the market today include hydrocodone (Hysingla ER, Zohydro ER), hydrocodone-acetaminophen (Norco, Zyfrel, others), fentanyl (Actiq, Duragesic, Fentora), oxycodone (OxyContin, Roxicodone, others), oxycodone-acetaminophen (Percocet, Roxicet, others) and many others. Ask your doctor if you don't know whether your painkiller is an opioid.

What a safe opioid taper involves

The right length for an opioid taper varies with each person and each medication. Your doctor will prescribe an opioid taper schedule that addresses your medical needs while minimizing risks to your health.

During your opioid taper, your doctor may:

  • Regularly monitor your pulse, blood pressure and temperature
  • Request urine or blood samples to check the type and amount of medication or other substances in your system
  • Ask for your permission to speak with your other health care providers, pharmacist or family members to obtain information that may help with your medication taper
  • Introduce other pain therapies as needed
  • Prescribe other types of medications to help you manage withdrawal signs and symptoms such as sleep, appetite and mood disturbances

Follow your withdrawal plan closely, especially your doctor's instructions about how and when to take medications during the taper. Although you may be eager to reach your goal, your body needs time to adjust to lower levels of opioids in your body, and then to none at all. A step-by-step reduction in your dose helps this process go smoothly and helps ease the discomfort you may feel when you stop taking opioids. It also allows you to practice new skills to manage pain and other chronic symptoms.

You may be tempted to take more medication than your taper requires. Don't supplement your taper with additional medications from home, visits to the emergency room, or with alcohol or street drugs. If you feel the need to supplement, contact your health care team.

Withdrawal symptoms

Some people experience withdrawal when they stop or reduce use of medication or other substances. Signs and symptoms of withdrawal include:

  • Restlessness or anxiety
  • Increased pain
  • Trouble sleeping
  • Nausea, vomiting or diarrhea
  • Sweating or fevers
  • Drowsiness
  • Tremors
  • Rapid heart rate
  • Blood pressure changes
  • Confusion
  • Hallucinations — seeing, hearing or feeling things that are not present — or seizures

If you experience withdrawal symptoms, tell a member of your health care team right away. Follow all instructions you receive about managing withdrawal symptoms.

Unless you are instructed otherwise, you may also find these tips helpful:

  • Drink more water or other liquids than usual.
  • Eat regular nutritious meals.
  • Use deep-breathing and stretching exercises, as instructed.
  • Exercise in moderation (for example, walking).
  • Do something to relax (for example, practice relaxation techniques, listen to music or read).
  • Use distraction (for example, humor, talking to someone with a positive outlook).
  • Use positive self-talk. Tell yourself "I can do this" or "This is only temporary."

The key role of social support

Talk with your doctor if the taper process becomes difficult. He or she, along with other members of your health care team, can assist and encourage your success. Your doctor may recommend combining your taper with counseling on medication use. In some cases, you may also wish to join a substance misuse support group (for example, Narcotics Anonymous) or talk with your religious or spiritual advisor.

Depending on your pattern of medication use, your doctor may recommend continued chemical dependence counseling after you've completed your opioid taper.

Considering opioid use in the future

If you have successfully tapered off opioid pain medication, you may someday be faced with an acute problem such as injury or surgery (not a flare-up of a chronic pain condition). In that case, taking opioids for a time may be appropriate. Tell your doctor that you have tapered off opioids in the past. He or she can help you to taper off opioid medications used to treat an acute problem.

Jan. 10, 2018 See more In-depth

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